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Autophagy regulation and its role in normal and malignant hematopoiesis
Author(s) -
Shahrabi Saeid,
Paridar Mostafa,
ZeinvandLorestani Marzieh,
Jalili Arsalan,
Zibara Kazem,
Abdollahi Mohammad,
Khosravi Abbas
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28903
Subject(s) - autophagy , haematopoiesis , biology , cancer research , suppressor , cancer , dual role , leukemia , microbiology and biotechnology , mechanism (biology) , stem cell , immunology , chemistry , apoptosis , genetics , combinatorial chemistry , philosophy , epistemology
Autophagy, the molecular machinery of self‐eating, plays a dual role of a tumor promoter and tumor suppressor. This mechanism affects different clinical responses in cancer cells. Autophagy is targeted for treating patients resistant to chemotherapy or radiation. Limited reports investigate the significance of autophagy in cancer therapy, the regulation of hematopoietic and leukemic stem cells and leukemia formation. In the current review, the role of autophagy is discussed in various stages of hematopoiesis including quiescence, self‐renewal, and differentiation.