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Autophagy and senescence: A new insight in selected human diseases
Author(s) -
Rajendran Peramaiyan,
Alzahrani Abdullah M,
Hanieh Hamza N,
Kumar Sekar Ashok,
Ben Ammar Rebai,
Rengarajan Thamaraiselavan,
Alhoot Mohammed A
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28895
Subject(s) - autophagy , senescence , telomere , microbiology and biotechnology , biology , programmed cell death , dna damage , cellular senescence , oxidative stress , genetics , apoptosis , gene , dna , biochemistry , phenotype
Senescence and autophagy play important roles in homeostasis. Cellular senescence and autophagy commonly cause several degenerative processes, including oxidative stress, DNA damage, telomere shortening, and oncogenic stress; hence, both events are known to be interrelated. Autophagy is well known for its disruptive effect on human diseases, and it is currently proposed to have a direct effect on triggering senescence and quiescence. However, it is yet to be proven whether autophagy has a positive or negative impact on senescence. It is known that elevated levels of autophagy induce cell death, whereas inadequate autophagy can trigger cellular senescence. Both have important roles in human diseases such as aging, renal degeneration, neurodegenerative disorders, and cancer. Therefore, this review aims to highlight the relevance of senescence and autophagy in selected human ailments through a summary of recent findings on the connection and effects of autophagy and senescence in these diseases.