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A red orange and lemon by‐products extract rich in anthocyanins inhibits the progression of diabetic nephropathy
Author(s) -
Damiano Sara,
Lombari Patrizia,
Salvi Erika,
Papale Massimo,
Giordano Antonio,
Amenta Margherita,
Ballistreri Gabriele,
Fabroni Simona,
Rapisarda Paolo,
Capasso Giovambattista,
Forte Iris Maria,
Barone Daniela,
Ciarcia Roberto
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28893
Subject(s) - oxidative stress , diabetic nephropathy , reactive oxygen species , diabetes mellitus , medicine , kidney disease , endocrinology , nephropathy , kidney , renal function , inflammation , chemistry , biochemistry
The major cause of end‐stage renal disease is the diabetic nephropathy. Oxidative stress contributes to the development of type II diabetes mellitus (T2DM). In this study we have evaluated the effect of a diet with a new standardized of red orange and lemon extract (RLE) rich in anthocyanins (ANT) in the progression of the kidney disease on Zucker diabetic fatty rats. Oxidative stress and renal function were analyzed. In diabetic rats, the RLE restored the blood glucose levels, body weight, and normalized the reactive oxygen species (ROS) total pathways. The kidney inflammation, in diabetic rats, has not shown significant change, showing that the oxidative stress rather than to inflammatory processes is a triggering factor in the renal complication associated with T2DM. Therefore, the administration of the RLE prevents this complication and this effect could be related to the inhibition of ROS production.