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Prospect of circular RNA in osteogenesis: A novel orchestrator of signaling pathways
Author(s) -
Huang Xinqi,
Cen Xiao,
Zhang Bo,
Liao Yuwei,
Zhu Guanyin,
Liu Jun,
Zhao Zhihe
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28866
Subject(s) - computational biology , circular rna , function (biology) , biology , osteoporosis , rna splicing , rna , bioinformatics , neuroscience , gene , microbiology and biotechnology , genetics , endocrinology
Circular RNAs (circRNAs) were initially regarded as by‐products of aberrant splicing. But now, there are substantial evidence on their various roles in the regulation of genes during the development of organs and diseases. Consistent with these breakthroughs, it is experiencing rapid growth that circRNAs function as the important checkpoints during the osteogenesis. Therefore, characterizing the roles of circRNAs is useful and critical to better understanding the process of osteogenic differentiation, which could provide new avenues for the diagnosis and treatment of bone diseases, such as bone defects and osteoporosis. In this review, we presented a map of the interaction between circRNAs and the molecules of signaling pathways associated with osteogenesis, summarized the current knowledge of the biological functions of circRNAs during the osteogenic differentiation, figured out the limits of existing research works, and provided a novel look on the diagnostic and therapeutic methods of bone diseases based on circRNAs.