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Circular RNA circMAN2B2 facilitates glioma progression by regulating the miR‐1205/S100A8 axis
Author(s) -
Xiong Jinsheng,
Wang Tianyao,
Tang Haitao,
Lv Zhonghua,
Liang Peng
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28860
Subject(s) - gene knockdown , glioma , cell growth , cancer research , cell , cell migration , chemistry , microbiology and biotechnology , biology , cell culture , biochemistry , genetics
The aim of this study was to research the mechanism of circMAN2B2 in the development of glioma. In our study, we found that circMAN2B2 has a higher expression in glioma tissues and cells, which was negatively related to the overall survival of glioma patients. The cell counting kit‐8 assay, 5‐ethynyl‐2′‐deoxyuridine labeling assay, transwell assay, and the nude mice assay indicated that knockdown of circMAN2B2 inhibited the cell proliferation, invasion, migration and decreased tumor size. In terms of mechanism, knockdown of circMAN2B2 increased the expression of miR‐1205. Moreover, circMAN2B2 regulated S100A8 expression by inhibiting miR‐1205. We also showed that knockdown of S100A8 inhibited cell proliferation, invasion, and migration. Increasing S100A8 expression rescued the effect of si‐circMAN2B2. In conclusion, circMAN2B2 could improve cell proliferation, invasion, and migration of the glioma by inhibiting miR‐1205 and promoting the expression of S100A8.