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Survivin a pivotal antiapoptotic protein in rheumatoid arthritis
Author(s) -
Zafari Parisa,
Rafiei Alireza,
Esmaeili SeyedAlireza,
Moonesi Mohammadreza,
Taghadosi Mahdi
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28784
Subject(s) - survivin , rheumatoid arthritis , apoptosis , cancer research , synovial membrane , inflammation , medicine , immunology , inhibitor of apoptosis , infiltration (hvac) , programmed cell death , cell , autoimmune disease , cell cycle , pathogenesis , biology , antibody , biochemistry , physics , genetics , thermodynamics
Rheumatoid arthritis (RA) is an autoimmune disease, pathologically characterized by lymphocyte infiltration of the synovial membrane that leads to chronic inflammation and progressive joint damage. RA develops as a result of increased cell infiltration and cell proliferation as well as impaired cell death. Activated cells in joints including lymphocytes and fibroblast‐like synoviocytes (FLS) survive for a long time as a consequence of compromised apoptosis, but the mechanism underlying cell survival in synovium remains to be firmly established. Inhibition of apoptosis by survivin, as a critical antiapoptotic protein, contributes to both the persistence of autoreactive T lymphocytes and tumor‐like phenotype of FLS in RA. In addition to the antiapoptotic role, survivin also has prognostic relevance in RA prodromal phase. Hence, this review provides an overview of the current knowledge regarding the involvement of survivin protein in the pathogenesis of RA.