Biology of MarR family transcription factors and implications for targets of antibiotics against tuberculosis | Zendy

Gong Zhen | Zendy; Li Hui | Zendy; Cai Yuhua | Zendy; Stojkoska Andrea | Zendy; Xie Jianping | Zendy

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Biology of MarR family transcription factors and implications for targets of antibiotics against tuberculosis

Author(s) -

Gong Zhen,

Li Hui,

Cai Yuhua,

Stojkoska Andrea,

Xie Jianping

Publication year - 2019

Publication title -

journal of cellular physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.529

H-Index - 174

eISSN - 1097-4652

pISSN - 0021-9541

DOI - 10.1002/jcp.28720

Subject(s) - tuberculosis , biology , mycobacterium tuberculosis , operon , antibiotics , transcription factor , transcription (linguistics) , multiple drug resistance , regulator , microbiology and biotechnology , genetics , gene , medicine , pathology , linguistics , philosophy , escherichia coli

Abstract The emergence of multidrug resistant (MDR) Mycobacterium tuberculosis strains and increased incidence of HIV coinfection fueled the difficulty in controlling tuberculosis (TB). MarR (multiple antibiotic resistance regulator) family transcription factors can regulate marRAB operon and are involved in resistance to multiple environmental stresses. We have summarized the structure, function, distribution, and regulation of the MarR family proteins, as well as their implications for novel targets for antibiotics, especially for tuberculosis.

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