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Biology of MarR family transcription factors and implications for targets of antibiotics against tuberculosis
Author(s) -
Gong Zhen,
Li Hui,
Cai Yuhua,
Stojkoska Andrea,
Xie Jianping
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28720
Subject(s) - tuberculosis , biology , mycobacterium tuberculosis , operon , antibiotics , transcription factor , transcription (linguistics) , multiple drug resistance , regulator , microbiology and biotechnology , genetics , gene , medicine , pathology , linguistics , philosophy , escherichia coli
The emergence of multidrug resistant (MDR) Mycobacterium tuberculosis strains and increased incidence of HIV coinfection fueled the difficulty in controlling tuberculosis (TB). MarR (multiple antibiotic resistance regulator) family transcription factors can regulate marRAB operon and are involved in resistance to multiple environmental stresses. We have summarized the structure, function, distribution, and regulation of the MarR family proteins, as well as their implications for novel targets for antibiotics, especially for tuberculosis.