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Transcription factor 7‐like 2‐associated signaling mechanism in regulating cementum generation by the NF‐κB pathway
Author(s) -
Zhao Zifan,
Dai Jing,
Yin Chengcheng,
Wang Xuzhu,
Wang Jinyang,
Jia Xiaoshi,
Zhao Qin,
Fu Hui,
Zhang Yufeng,
Xia Haibin
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28685
Subject(s) - transcription factor , microbiology and biotechnology , mechanism (biology) , signal transduction , nf κb , nfkb1 , transcription (linguistics) , chemistry , biology , genetics , gene , philosophy , linguistics , epistemology
Cementum regeneration is an important and challenging stage in periodontal tissue engineering and regeneration. Pathosis of the periodontium, including cementum, is important in precision diagnosis and obstinate treatment of systemic diseases, such as diabetes, leukemia, and Acquired Immune Deficiency Syndrome. Here, we found that during periodontium development, transcription factor 7‐like 2 (Tcf7l2) was widely expressed in the periodontium and dental sac. In mouse cementoblast cell line (OCCM‐30), the activation of NF‐κB and cementoblast mineralization was significantly reduced when Tcf7l2 gene was silenced. Moreover, Tcf7l2 has a positive effect on NF‐κB and cementoblast mineralization. Therefore, Tcf7l2 promotes cementum formation through the NF‐κB pathway. In addition, we found a decreased expression of phosphorylated p65 and a thin layer of cementum in Tcf7l2 fl/fl mice. These results suggest that Tcf7l2, which accelerates cementum formation by activating NF‐κB, has great potential in the treatment of periodontitis and provide guidance for periodontal tissue regeneration.