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Exosome‐based intercellular communication in female reproductive microenvironments
Author(s) -
Ranjbaran Ali,
Latifi Zeinab,
Nejabati Hamid Reza,
Abroon Sina,
Mihanfar Aynaz,
Sadigh Aydin Raei,
Fattahi Amir,
Nouri Mohammad,
Raffel Nathalie
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28668
Subject(s) - microvesicles , multicellular organism , biology , exosome , epigenetics , female reproductive tract , epigenome , population , microbiology and biotechnology , computational biology , microrna , gene , genetics , medicine , gene expression , sperm , environmental health , dna methylation
Different strategies are applied for cellular cross‐talk and organization in multicellular organisms. Exosomes are a homogenous population of biological nanoparticles (30–100 nm), originated from multivesicular bodies. The exosomes (Exos) could regulate and affect both cellular physiology and pathophysiology in various organs, such as the female reproductive tract, by altering gene pathways and/or epigenetic programming. Besides, engineered Exos have the potential to be used as a novel drug and gene delivery tools. Here in this review, we discussed various aspects of exosome‐based intercellular communication in female reproductive microenvironments. Furthermore, we addressed the findings and issues related to Exos in reproductive biology to give a better view of the involved molecular mechanisms. Moreover, clinical applications of the Exos and their isolation source/methods have been considered to throw some light on the progression of new biological, diagnostic, and therapeutic approaches in clinical embryology.