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The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis: Basic science and new insights based on gene expression
Author(s) -
Samimi Mansooreh,
Pourhanifeh Mohammad Hossein,
Mehdizadehkashi Abolfazl,
Eftekhar Tahereh,
Asemi Zatollah
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28666
Subject(s) - endometriosis , pathophysiology , angiogenesis , oxidative stress , inflammation , infertility , medicine , cancer research , bioinformatics , apoptosis , stroma , immunology , pathology , biology , immunohistochemistry , genetics , pregnancy
Endometriosis is a frequent and chronic illness in young women which could be defined by the existence of endometrial stroma and glands outside of the normal site of the lining of the uterus. It has painful symptoms. The advanced stage of endometriosis may lead to gynecological malignancies, such as ovarian cancer, and other complications, including infertility. However, its exact physiopathology is not well known. Recent studies have shown the possible roles of inflammation along with oxidative stress. Additionally, angiogenesis and apoptosis dysregulation contribute to endometriosis pathophysiology. Therapeutic strategies and continuing attempts, to conquer endometriosis should be done regarding molecular signaling pathways. Thus, the present review summarizes current studies and focuses on molecular mechanisms.