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Clinical prognostic evaluation of immunocytes in different molecular subtypes of breast cancer
Author(s) -
Zenan Huang,
Zixiong Li,
Zhicheng Yao,
Mei Huang,
Xiongbin Yang,
Tiantian Wang,
Min Dong,
Renbin Liu,
Changchang Jia
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28662
Subject(s) - medicine , monocyte , breast cancer , lymphocyte , multivariate analysis , eosinophil , oncology , univariate analysis , gastroenterology , neutrophil to lymphocyte ratio , lymph node , cancer , pathology , asthma
To retrospectively analyze the relationship between preoperative blood parameters and postoperative clinical outcomes in patients with different molecular subtypes of breast cancer (BC), a cohort of 601 patients with BC in the Third Affiliated Hospital, Sun Yat‐sen University, was retrospectively reviewed. They were categorized into four subtypes according to the expression of ER, PR, HER‐2, and KI‐67%. White blood cell, neutrophil, lymphocyte, monocyte, eosinophil, basophil, and platelet counts, the neutrophil‐to‐lymphocyte ratio (NLR), the neutrophil‐to‐monocyte ratio (NMR), the lymphocyte‐to‐monocyte ratio (LMR), and the platelet‐to‐lymphocyte ratio (PLR) were recorded. Univariate and multivariate analyses were performed to identify the relationship between parameters and ratios and disease‐free survival (DFS) and overall survival (OS). Luminal subtypes of BC had smaller tumor volume, better differentiation degree of invasive ductal carcinoma, less lymph node metastasis, and better clinical outcome than the HER‐2 overexpression and triple‐negative BC (TNBC) subtypes. In multivariate analysis, age and LMR were the independent prognostic factors of DFS in patients with luminal A (age, p = 0.005; LMR, P = 0.026); PLR in patients with luminal B (DFS; p = 0.032; OS, p = 0.012); LMR in patients with HER‐2 overexpression (DFS; p = 0.008; OS, p = 0.017); and NLR for DFS ( p = 0.014); and WBC for OS ( p = 0.008) in patients with TNBC. LMR was the benign predictor of luminal A and HER‐2 overexpression. PLR was the adverse predictor of luminal B. WBC and NLR were the adverse predictors of TNBC. Therefore, these peripheral blood parameters can play an important role in the diagnosis and treatment of patients with different molecular subtypes of BC.