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Thyroid autoimmune diseases and thyroid tumors: Would EBV infection be the link?
Author(s) -
Almeida Jacqueline Fátima Martins,
Ward Laura Sterian
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28641
Subject(s) - thyroid , thyroid cancer , carcinogenesis , medicine , virus , in situ hybridization , pathology , immunology , follicular cell , cancer , cancer research , biology , messenger rna , gene , biochemistry
The role of EBV in thyroid cancer development and the patient's outcome is still unclear. Using nested‐PCR, Moghoofei et al. reported a high incidence of a virus in thyroid tumor samples, different from our results, obtained by quantitative real‐time PCR and confirmed by in situ hybridization. Because lymphocytes are the main reservoir of the virus and tumor‐infiltrating lymphocytes are commonly observed in thyroid cancer, it is important to distinguish follicular cells infection from lymphoid tissue infection. The association between autoimmune diseases and thyroid cancer raises the importance of continuing to investigate the role of ubiquitous pathogens in thyroid tumorigenesis.