Premium
Oncogenic effects of exosomes in γ‐herpesvirus‐associated neoplasms
Author(s) -
Zheng Jiayu,
Shi Yiwan,
Feng Zhenyu,
Zheng Yilu,
Li Zhanhao,
Zhao Yi,
Wang Yan
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28573
Subject(s) - microvesicles , carcinogenesis , biology , immune system , epstein–barr virus , virus , immune dysfunction , gammaherpesvirinae , neoplastic transformation , cancer research , virology , herpesviridae , immunology , microrna , cancer , viral disease , genetics , gene
Kaposi's sarcoma‐associated herpesvirus (KSHV) and Epstein–Barr virus (EBV) are herpesviruses associated with human malignancies. As exosomes can shuttle many herpesvirus‐associated biomolecules from host cells to recipient cells, the exosomal pathway is utilized by herpesviruses to achieve extensive infections and even oncogenesis. In this review, we discuss the oncogenic biomolecules present in exosomes derived from KSHV‐ and EBV‐infected cells. Moreover, oncogenesis via exosomal biomolecules mainly occurs through three processes, including regulation of downstream signals, promotion of immune dysfunction and transformation of cells. Also, the exosomes may provide diagnostic markers and therapeutic targets specific for KSHV‐ and EBV‐associated malignancies.