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Effect of pomegranate seed oil supplementation on the GLUT‐4 gene expression and glycemic control in obese people with type 2 diabetes: A randomized controlled clinical trial
Author(s) -
Khajebishak Yaser,
Payahoo Laleh,
Alivand Mohammadreza,
Hamishehkar Hamed,
Mobasseri Majid,
Ebrahimzadeh Vahide,
Alipour Mahdiye,
Alipour Beitollah
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28561
Subject(s) - medicine , glycemic , type 2 diabetes , insulin , diabetes mellitus , placebo , type 2 diabetes mellitus , endocrinology , glycemic index , blood sugar , randomized controlled trial , quantitative insulin sensitivity check index , glucose transporter , insulin resistance , insulin sensitivity , pathology , alternative medicine
Abnormality in glucose transporter type 4 (GLUT‐4) function and insulin secretion are the main causes of type 2 diabetes mellitus (T2DM). Due to adverse effects of antidiabetic drugs, nowadays, nutraceuticals have been of much interest to investigators. The aim of the present study was to determine the effect of pomegranate seed oil (PSO) on the GLUT‐4 gene expression and glycemic control in obese people with T2DM. This randomized clinical trial was conducted on 52 obese type 2 diabetic patients for 8 weeks in Tabriz, Iran, in 2018. Patients were divided into the intervention group ( n = 26; who consumed daily three capsules containing 1 g PSO) and the placebo group ( n = 26; the same amounts paraffin). GLUT‐4 gene expression and glycemic indices were evaluated by standard methods. GLUT‐4 gene expression was increased significantly in the PSO group. Within‐group changes in fasting blood sugar (FBS) and quantitative insulin sensitivity check index were significant in the PSO group. After adjusting the age, gender, and baseline values, FBS was significantly decreased. Insulin concentration, HbA1C, HOMA‐IR, and HOMA‐β did not manifest significant changes. PSO increased the GLUT‐4 gene expression in diabetic patients without any side effects. However, future clinical studies are needed to confirm the obtained results.