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Hepatoprotective effect of Aloe vera against cartap‐ and malathion‐induced toxicity in Wistar rats
Author(s) -
Gupta Vivek K.,
Siddiqi Nikhat J.,
Ojha Anil K.,
Sharma Bechan
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28466
Subject(s) - malathion , cartap , aloe vera , malondialdehyde , glutathione , superoxide dismutase , toxicity , chemistry , oxidative stress , toxicology , pharmacology , pesticide , traditional medicine , biochemistry , medicine , enzyme , biology , agronomy , organic chemistry
Exposure to mixture of pesticides in agricultural practices pose a serious threat to the nontarget animals. In present work, we have evaluated the synergistic effect of cartap and malathion on rat liver followed by impact of Aloe vera leaves aqueous extract, which is not known. The animals in eight groups were used; each containing six rats: Group 1 acted as a control, Group 2—control with A. vera leaves aqueous extract, Group 3—with cartap, Group 4—with malathion, Group 5—with mixture of cartap and malathion, Group 6—cartap with the pretreatment of A. vera leaf extract, Group 7—malathion with the pretreatment of A. vera leaf extract, Group 8—mixture of cartap and malathion with the pretreatment of A. vera leaf extract . The animals treated for 15 days were killed after 24hr of last treatment. The biochemical studies in the rat liver demonstrated significant perturbations in the levels of nonenzymatic (glutathione and malondialdehyde) and enzymatic (superoxide dismutase, catalase, and glutathione‐ S ‐transferase) antioxidative indices. The histopathological examination of liver revealed serious congestion in central vein and the disorganization of hepatic cords due to pesticide treatment. The administration of A. vera leaves aqueous extract was able to markedly protect rat liver from the pesticides‐induced toxicity. The data indicated that pesticides were able to significantly induce oxidative stress which was substantially reduced by the application of plant extract .