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Antiplatelet, antioxidative, and anti‐inflammatory effects of hydroquinone
Author(s) -
Chang MeiChi,
Chang BeiEn,
Pan YuHwa,
Lin BorRu,
Lian YunChia,
Lee MingShu,
Yeung SinYuet,
Lin LiDeh,
Jeng JiiangHuei
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28444
Subject(s) - chemistry , platelet , arachidonic acid , ex vivo , thromboxane , in vivo , thromboxane b2 , pharmacology , hydroquinone , hemostasis , bleeding time , thromboxane a2 , biochemistry , platelet aggregation , food science , in vitro , immunology , medicine , biology , microbiology and biotechnology , receptor , enzyme
Platelets play crucial roles in thrombosis and hemostasis through platelet activation and aggregation that are crucial in cardiovascular diseases. Hydroquinone (HQ) and its derivatives are present in many dermatological creams, paints, motor fuels, air, microorganisms, and plant products like wheat bread, fruit, coffee, and red wine. The effect of HQ on humans is not clear. In this study, we found that HQ (>25 μM) inhibited arachidonic acid (AA)‐induced platelet aggregation. HQ suppressed AA‐induced thromboxane B2 production of platelets. HQ (>10 μM) also attenuated ex vivo platelet‐rich plasma aggregation. HQ prevented the interleukin (IL)‐1β‐induced 8‐isoprostane, and PGE2 production, but not IL‐8 production of pulp cells. These results indicate that HQ may have an antiplatelet effect via inhibition of thromboxane production. HQ has antioxidative and anti‐inflammatory effects, and possible inhibition of COX. Exposure and consumption of HQ‐containing products, food or drugs may have antiplatelet, antioxidative, and anti‐inflammatory effects.