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Emerging role for Ureaplasma parvum serovar 3: Active infection in women with silent high‐risk human papillomavirus and in women with idiopathic infertility
Author(s) -
Zanotta Nunzia,
Campisciano Giuseppina,
Morassut Sara,
CastroSilva Eugenia,
Luksa Viviana,
Zito Gabriella,
Luppi Stefania,
Martinelli Monica,
Colli Claudia,
Seta Francesco,
Ricci Giuseppe,
Suligoi Barbara,
Comar Manola
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28423
Subject(s) - ureaplasma , infertility , cervicitis , ureaplasma urealyticum , mycoplasma , coinfection , medicine , serotype , gynecology , obstetrics , biology , immunology , virology , pregnancy , microbiology and biotechnology , virus , genetics
Recently, there are controversial opinions on the presence of Mycoplasmas / Ureaplasmas as colonizers or pathogens, and on the use of a targeted therapy. This study aimed to characterize Mycoplasmas / Ureaplasmas infections in reproductive age women, including the acquisition of sexually transmitted (ST) pathogens and poor birth outcomes. A total of 646 healthy Italian women fulfilled the inclusion criteria including 521 infertile women, 65 pregnant women, and 60 fertile women with identified risk factors and symptomatic for vaginitis/cervicitis. Multiplex and quantitative molecular techniques and direct automatic DNA sequencing were performed to assess the genome structure of Mycoplasma/Ureaplasma species and ST infected pathogens. Ureaplasma parvum serovar 3 represented the predominant colonizer of the urogenital tract of this series and the unique species significantly associated with ST pathogens coinfection ( p < 0.01). U. parvum load >10 4 bacteria/ml, suggestive of active infection, has been measured only in asymptomatic high‐risk human papillomavirus infected women (24.3%) and in 40% of women with idiopathic infertility. To note, 16% of the follicular fluid from these idiopathic women resulted infected with U. parvum . In conclusion, the present study focused the attention on U. parvum serovar 3 as emerging microorganism in sexually active women that may have the benefit of targeted therapy.