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Gene therapy in rheumatoid arthritis: Strategies to select therapeutic genes
Author(s) -
Zavvar Mahdi,
Assadiasl Sara,
Soleimanifar Narjes,
Pakdel Fatemeh Dadgar,
Abdolmohammadi Kamal,
Fatahi Yousef,
Abdolmaleki Mohsen,
Baghdadi Hamed,
Tayebi Lobat,
Nicknam Mohammad H.
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28392
Subject(s) - genetic enhancement , rheumatoid arthritis , medicine , gene , gene transfer , proinflammatory cytokine , arthritis , immune system , bioinformatics , computational biology , immunology , biology , inflammation , genetics
Abstract Significant advances have been achieved in recent years to ameliorate rheumatoid arthritis (RA) in animal models using gene therapy approaches rather than biological treatments. Although biological agents serve as antirheumatic drugs with suppressing proinflammatory cytokine activities, they are usually accompanied by systemic immune suppression resulting from continuous or high systemic dose injections of biological agents. Therefore, gene transfer approaches have opened an interesting perspective to deliver one or multiple genes in a target‐specific or inducible manner for the sustained intra‐articular expression of therapeutic products. Accordingly, many studies have focused on gene transferring methods in animal models by using one of the available approaches. In this study, the important strategies used to select effective genes for RA gene therapy have been outlined. Given the work done in this field, the future looks bright for gene therapy as a new method in the clinical treatment of autoimmune diseases such as RA, and by ongoing efforts in this field, we hope to achieve feasible, safe, and effective treatment methods.