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Stem cell therapy: A novel approach for myocardial infarction
Author(s) -
Parizadeh Seyed Mostafa,
JafarzadehEsfehani Reza,
Ghandehari Maryam,
Parizadeh Mohammad Reza,
Ferns Gordon A.,
Avan Amir,
Hassanian Seyed Mahdi
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28381
Subject(s) - stem cell , regeneration (biology) , paracrine signalling , stem cell therapy , myocardial infarction , medicine , neovascularization , inflammation , regenerative medicine , cell therapy , cardiology , infarction , cancer research , bioinformatics , angiogenesis , microbiology and biotechnology , biology , receptor
Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide. Until recently, it was thought that myocardium was not able to repair itself, but studies have now shown that resident cardiac stem cells have regenerative capacity, and stem cell therapy may be a novel approach for cardiac muscle repair and regeneration. Stem cell‐derived paracrine factors have been shown to regulate ventricular remodeling, inflammation, apoptosis, cardiomyocytes regeneration, and neovascularization in regions of infarcted cardiac tissue. In this review, we summarize the evidence from cellular, animal, and clinical studies supporting the potential clinical significance of stem cell therapy as a novel therapeutic approach for the treatment of MI.