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Targeting autophagy in cardiac ischemia/reperfusion injury: A novel therapeutic strategy
Author(s) -
Aghaei Mehrdad,
Motallebnezhad Morteza,
Ghorghanlu Sajjad,
Jabbari Ali,
Enayati Ayesheh,
Rajaei Maryam,
Pourabouk Mona,
Moradi Alireza,
Alizadeh Ali Mohammad,
Khori Vahid
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28345
Subject(s) - autophagy , reperfusion injury , myocardial infarction , medicine , ischemia , reactive oxygen species , pharmacology , therapeutic approach , cardiology , microbiology and biotechnology , apoptosis , biology , biochemistry , disease
Acute myocardial infarction (AMI) is one of the leading causes of morbidity worldwide. Myocardial reperfusion is known as an effective therapeutic choice against AMI. However, reperfusion of blood flow induces ischemia/reperfusion (I/R) injury through different complex processes including ion accumulation, disruption of mitochondrial membrane potential, the formation of reactive oxygen species, and so forth. One of the processes that gets activated in response to I/R injury is autophagy. Indeed, autophagy acts as a “double‐edged sword” in the pathology of myocardial I/R injury and there is a controversy about autophagy being beneficial or detrimental. On the basis of the autophagy effect and regulation on myocardial I/R injury, many studies targeted it as a therapeutic strategy. In this review, we discuss the role of autophagy in I/R injury and its targeting as a therapeutic strategy.