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Long noncoding RNA OIP5‐AS1 acts as a competing endogenous RNA to promote glutamine catabolism and malignant melanoma growth by sponging miR‐217
Author(s) -
Luan Wenkang,
Zhang Xuanfeng,
Ruan Hongru,
Wang Jinlong,
Bu Xuefeng
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28335
Subject(s) - endogeny , rna , catabolism , competing endogenous rna , glutamine , melanoma , biology , long non coding rna , non coding rna , cancer research , biochemistry , metabolism , microbiology and biotechnology , gene , amino acid
The long noncoding RNA (lncRNA) OIP5‐AS1 has been considered to promote the growth and metastasis of many human tumors. However, the role of OIP5‐AS1 in melanoma has not been reported. In this study, we found that OIP5‐AS1 levels were significantly elevated in melanoma tissue and that high OIP5‐AS1 expression was an independent risk factor for the poor survival of patients with melanoma. miR‐217 suppressed glutamine catabolism in melanoma cells by targeting glutaminase (GLS), the rate‐limiting enzyme of glutamine catabolism. We also demonstrated that OIP5‐AS1 acted as a sponge of miR‐217 to upregulate GLS expression, thus promoting glutamine catabolism and melanoma growth. Overall, this result elucidates a new mechanism for OIP5‐AS1 in metabolism in melanoma and provides a potential therapeutic target for patients with melanoma.