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Influence of forkhead box protein 3 polymorphisms (rs2232365, rs3761548) with the outcome of pregnancy: A meta‐analysis
Author(s) -
Hosseini Teshnizi Saeed,
AliHassanzadeh Mohammad,
GharesiFard Behrouz,
Kabelitz Dieter,
Kalantar Kurosh
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28328
Subject(s) - allele , foxp3 , odds ratio , meta analysis , pregnancy , genotype , single nucleotide polymorphism , immune system , medicine , immunology , biology , oncology , genetics , gene
Dysfunction of regulatory T cells (Tregs) may contribute to certain immune‐related pregnancy complications. Forkhead box protein 3 ( FOXP3 ) is the key transcription factor of Treg. We performed a systematic review and meta‐analysis to evaluate the possible association between FOXP3 polymorphisms −924A/G (rs2232365) and −3279C/A (rs3761548) and immune‐related pregnancy complications. After reviewing 78 fully published studies, 10 studies fulfilled previously defined eligibility criteria and were used for meta‐analysis. Two single nucleotide polymorphisms showed a significant correlation with increased or reduced risk for immune‐related pregnancy complications. For rs3761548, women with allele A were significantly at a higher risk than women carrying allele C (odds ratio = 1.29, 95% confidence interval: 1.20–1.38; p = 0.001). For rs2232365, women with GG or AG genotype were at a higher risk than women with genotype AA, thereby, allele G was significantly associated with a higher risk than allele A. Our meta‐analysis supports the notion that immune‐related pregnancy complications might be linked to genetic variations in the FOXP3 gene.