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Use of stem cells as carriers of oncolytic viruses for cancer treatment
Author(s) -
Zendedel Elham,
Atkin Stephen L.,
Sahebkar Amirhossein
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28320
Subject(s) - oncolytic virus , homing (biology) , virotherapy , cancer stem cell , stem cell , cancer cell , cancer , cancer therapy , cancer research , cancer treatment , biology , virology , medicine , tumor cells , microbiology and biotechnology , ecology
Therapeutic application of stem cells and oncolytic viruses in cancer treatment has rapidly increased in the last decade. Oncolytic viruses are considered as a new class of anticancer agents because of their ability to selectively infect and destroy cancer cells. Furthermore, regarding the specific migratory capacity of stem cells, they can be used as carriers or vectors targeting metastatic cancer. Promising results have been reported regarding the use of stem cells and oncolytic viruses as a therapeutic approach for the treatment of metastatic cancer. The present review aimed to determine the approaches involved in the use of the tumor‐homing capacity of stem cells for cancer treatment.