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Current approaches in identification and isolation of cancer stem cells
Author(s) -
Akbarzadeh Maryam,
Maroufi Nazila Fathi,
Tazehkand Abbas Pirpour,
Akbarzadeh Moloud,
Bastani Sepideh,
Safdari Reza,
Farzane Ali,
Fattahi Amir,
Nejabati Hamid Reza,
Nouri Mohammad,
Samadi Nasser
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28271
Subject(s) - cancer stem cell , isolation (microbiology) , carcinogenesis , identification (biology) , cancer , cancer research , computational biology , cancer cell , biology , medicine , bioinformatics , genetics , botany
Cancer stem cells (CSCs) are tumor cells with initiating ability, self‐renewal potential, and intrinsic resistance to conventional therapeutics. Efficient isolation and characterization of CSCs pave the way for more comprehensive knowledge about tumorigenesis, heterogeneity, and chemoresistance. Also a better understanding of CSCs will lead to novel era of both basic and clinical cancer research, reclassication of human tumors, and development of innovative therapeutic strategies. Finding novel diagnostic and effective therapeutic strategies also enhance the success of treatment in cancer patients. There are various methods based on the characteristics of the CSCs to detect and isolate these cells, some of which have recently developed. This review summarized current techniques for effective isolation and characterization of CSCs with a focus on advantages and limitations of each method with clinical applications.