Premium
Therapeutic potency of crocin in the treatment of inflammatory diseases: Current status and perspective
Author(s) -
Pashirzad Mehran,
Shafiee Mojtaba,
Avan Amir,
Ryzhikov Mikhail,
Fiuji Hamid,
Bahreyni Amirhossein,
Khazaei Majid,
Soleimanpour Saman,
Hassanian Seyed Mahdi
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28177
Subject(s) - medicine , crocin , psoriasis , phytomedicine , pharmacology , immunology , traditional medicine
Crocin is the major component of saffron, which is used in phytomedicine for the treatment of several diseases including diabetes, fatty liver, depression, menstruation disorders, and, of special interest in this review, inflammatory diseases. Promising selective anti‐inflammatory properties of this pharmacological active component have been observed in several studies. Saffron has been shown to exert anti‐inflammatory properties against several inflammatory diseases and can be used as a novel therapeutic agent for the treatment of inflammatory diseases either alone or in combination with other standard anti‐inflammatory agents. This review summarizes the protective role of saffron and its pharmacologically active constituents in the pathogenesis of inflammatory diseases including digestive diseases, dermatitis, asthma, atherosclerosis, and neurodegenerative diseases for a better understanding and hence a better management of these diseases.