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Role of TGF‐β signaling regulatory microRNAs in the pathogenesis of colorectal cancer
Author(s) -
Soleimani Atena,
Khazaei Majid,
Ferns Gordon A,
Ryzhikov Mikhail,
Avan Amir,
Hassanian Seyed Mahdi
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28169
Subject(s) - microrna , cancer research , signal transduction , transforming growth factor , angiogenesis , metastasis , colorectal cancer , pathogenesis , biology , suppressor , cancer , mouse model of colorectal and intestinal cancer , cell growth , transforming growth factor beta , medicine , immunology , microbiology and biotechnology , gene , genetics
Transforming growth factor β (TGF‐β) modulates tumor progression by regulating cell proliferation, apoptosis, metastasis, angiogenesis, and drug resistance. Biological and pharmacological agonists/antagonists, the interplay between intracellular signaling pathways, and microRNAs (miRNAs) control the initiation and activation of the TGF‐β signaling pathway. It has been proposed that the expression profiles of tumor suppressor and oncogenic TGF‐β miRNAs may be used for the classification, diagnosis, and prognosis of human malignancies. Deregulated miRNAs and aberrant activation of TGF‐β signaling are frequently found in human colorectal cancers (CRCs), but a little is known about their mechanisms of action in the development and progression of colorectal carcinoma. This review summarizes the current knowledge of the role of TGF‐β signaling regulatory miRNAs in the pathogenesis of CRC for a better understanding and hence better management of this disease.