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SNHG20: A vital lncRNA in multiple human cancers
Author(s) -
Zhao Wei,
Ma Xiaozhou,
Liu Lina,
Chen Qingyu,
Liu Zihao,
Zhang Zheng,
Ma Shiqing,
Wang Zhonghou,
Li Hongfa,
Wang Zuomin,
Wu Jie
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28143
Subject(s) - biology , carcinogenesis , small nucleolar rna , cancer , long non coding rna , gene , colorectal cancer , ovarian cancer , rna , cancer research , genetics
Long noncoding RNAs (lncRNAs) act as an initial factor and promoter in different tumors as a kind of ncRNAs. The length of them is >200 nucleotides opposite small ncRNAs. Increasing researches have proved that dysregulation lncRNA has been implicated in tumorigenesis. Small nucleolar RNA host gene 20 (SNHG20), a member of lncRNAs, expresses frequently in cancer types, such as hepatocellular carcinoma, ovarian cancer, colorectal cancer, and bladder cancer, contributing to cancer development and progression by transcriptional or posttranscriptional modifications. Not only does this review show the recent published literature concerning the biological functions but also demonstrates molecular mechanisms of SNHG20 among above multiple malignancies and others.