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Human unrestricted somatic stem cells ameliorate sepsis‐related acute lung injury in mice
Author(s) -
Behjani Zeinab Zarei,
Ai Jafar,
Soleimani Masoud,
Atashi Amir,
Taheri Behnaz,
EbrahimiBarough Somayeh,
Siavashi Vahid,
Shirian Sadegh,
Hamidieh Amir Ali
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28077
Subject(s) - somatic cell , sepsis , stem cell , lung , medicine , biology , immunology , microbiology and biotechnology , gene , genetics
Background Aims Sepsis and related disorders, especially acute lung injury (ALI), are the most challenging life‐threatening diseases in the hospital intensive care unit. Complex pathophysiology, unbalanced immune condition, and high rate of mortality complicate the treatment of sepsis. Recently, cell therapy has been introduced as a promising option to recover the sepsis symptoms. The aim of this study was to investigate the therapeutic potential of human unrestricted somatic stem cells (USSCs) isolated from human umbilical cord blood in the mouse model of ALI. USSCs significantly enhanced the survival rate of mice suffering from ALI and suppressed concentrations of proinflammatory mediators TNF‐α, and interleukin (IL)‐6, and the level of anti‐inflammatory cytokine IL‐10. ALI mice injected by USSCs showed notable reduction in lung and liver injury, pulmonary edema, and hepatic enzymes, compared with the control group. These results determined the in vivo immunomodulatory effect of USSCs for recovery of immune balance and reduction of tissue injury in the mouse model of ALI. Therefore, USSCs can be a suitable therapeutic approach to manage sepsis disease through the anti‐inflammatory potential.