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Long noncoding RNA MNX1‐AS1 contributes to lung cancer progression through the miR‐527/BRF2 pathway
Author(s) -
Liu Haibo,
Han Leng,
Liu Zhengjia,
Gao Nan
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28064
Subject(s) - gene knockdown , long non coding rna , lung cancer , cancer research , biology , carcinogenesis , ovarian cancer , downregulation and upregulation , tumor progression , cancer , medicine , gene , oncology , genetics
Lung cancer belongs to a leading popular and malignant cancer around the world. However, the root mechanism underlying lung cancer progression remains unclear. Recently, long noncoding RNA (lncRNA) has been identified as important for tumorigenesis. LncRNA MNX1‐AS1 is proven to regulate colon adenocarcinoma, cervical cancer, glioblastoma, and ovarian cancer. Whether MNX1‐AS1 participates in lung cancer needs investigation. In our research, we found that MNX1‐AS1 was dramatically upregulated in lung cancer. MNX1‐AS1 upregulation indicated poor prognosis in lung cancer patients. Functionally, MNX1‐AS1 promoted lung cancer progression through regulating proliferation, migration, and invasion. Mechanistically, MNX1‐AS1 was found to locate in the cytoplasm and interact with miR‐527. Through inhibiting miR‐527 availability, MNX1‐AS1 facilitated BRF2 expression. Restoration of BRF2 rescued defects of proliferation, migration, and invasion caused by MNX1‐AS1 knockdown. Taken together, our study found a novel signaling pathway, namely MNX1‐AS1/miR‐527/BRF2 axis, involved in lung cancer progression.