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Magnetoelectric nanocomposite scaffold for high yield differentiation of mesenchymal stem cells to neural‐like cells
Author(s) -
Esmaeili Elaheh,
Soleimani Masoud,
Ghiass Mohammad Adel,
Hatamie Shadie,
Vakilian Saeed,
Zomorrod Mahsa Soufi,
Sadeghzadeh Negar,
Vossoughi Manouchehr,
Hosseinzadeh Simzar
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.28040
Subject(s) - mesenchymal stem cell , materials science , nanofiber , scaffold , nanocomposite , piezoelectricity , nanoparticle , neural tissue engineering , tissue engineering , nanotechnology , neural stem cell , stem cell , polymer , biomedical engineering , composite material , microbiology and biotechnology , medicine , biology
While the differentiation factors have been widely used to differentiate mesenchymal stem cells (MSCs) into various cell types, they can cause harm at the same time. Therefore, it is beneficial to propose methods to differentiate MSCs without factors. Herein, magnetoelectric (ME) nanofibers were synthesized as the scaffold for the growth of MSCs and their differentiation into neural cells without factors. This nanocomposite takes the advantage of the synergies of the magnetostrictive ller, CoFe 2 O 4 nanoparticles (CFO), and piezoelectric polymer, polyvinylidene difluoride (PVDF). Graphene oxide nanosheets were decorated with CFO nanoparticles for a proper dispersion in the polymer through a hydrothermal process. After that, the piezoelectric PVDF polymer, which contained the magnetic nanoparticles, underwent the electrospun process to form ME nanofibers, the ME property of which has the potential to be used in areas such as tissue engineering, biosensors, and actuators.