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Mycobacterium avium complex infection in patients with human immunodeficiency virus: A systematic review and meta‐analysis
Author(s) -
Heidary Mohsen,
Nasiri Mohammad Javad,
Mirsaeidi Mehdi,
Jazi Faramarz Masjedian,
Khoshnood Saeed,
Drancourt Michel,
DarbanSarokhalil Davood
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27859
Subject(s) - mycobacterium avium complex , medicine , human immunodeficiency virus (hiv) , meta analysis , confidence interval , opportunistic infection , sida , immunology , aids related opportunistic infections , immunopathology , virology , viral disease
Abstract Background Mycobacterium avium ‐intracellulare complex (MAC) is one of the leading causes of death among people living with human immunodeficiency virus (HIV). The current study was aimed to determine the frequency of MAC infection in patients infected with HIV. Methods Embase, PubMed, and Web of Science were searched for relevant studies. All statistical analyses were performed by STATA version 14. Results From 6,627 retrieved articles, 23 were included in the final analysis. A total of 18,463 patients with HIV were included in the analysis. The frequency of MAC infection in patients with HIV was found to be 10.6% (95% confidence interval, 6.9–14.2). Conclusion The relatively large fractions of HIV‐infected patients were coinfected with MAC, which may poses significant public health problems. Continued progress in the development of rapid diagnostic methods and preventive therapy for MAC should lead to further improvements in survival and quality of life in patients with HIV.