Premium
Immunoresolvents in asthma and allergic diseases: Review and update
Author(s) -
Lotfi Ramin,
Rezaiemanesh Alireza,
Mortazavi Seyed Hamidreza,
Karaji Ali Gorgin,
Salari Farhad
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27836
Subject(s) - asthma , medicine , allergic asthma , immunology , intensive care medicine , dermatology
Asthma and allergic diseases are inflammatory conditions developed by excessive reaction of the immune system against normally harmless environmental substances. Although acute inflammation is necessary to eradicate the damaging agents, shifting to chronic inflammation can be potentially detrimental. Essential fatty‐acids‐derived immunoresolvents, namely, lipoxins, resolvins, protectins, and maresins, are anti‐inflammatory compounds that are believed to have protective and beneficial effects in inflammatory disorders, including asthma and allergies. Accordingly, impaired biosynthesis and defective production of immunoresolvents could be involved in the development of chronic inflammation. In this review, recent evidence on the anti‐inflam]matory effects of immunoresolvents, their enzymatic biosynthesis routes, as well as their receptors are discussed.