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EW‐7197 prevents ulcerative colitis‐associated fibrosis and inflammation
Author(s) -
Binabaj Maryam M.,
Asgharzadeh Fereshteh,
Avan Amir,
Rahmani Farzad,
Soleimani Atena,
Parizadeh Mohammad R.,
Ferns Gordon A.,
Ryzhikov Mikhail,
Khazaei Majid,
Hassanian Seyed M.
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27823
Subject(s) - ulcerative colitis , colitis , inflammation , fibrosis , medicine , proinflammatory cytokine , inflammatory bowel disease , oxidative stress , edema , immunology , pathology , disease
EW‐7197 is a transforming growth factor‐β type I receptor kinase inhibitor with potential anti‐inflammatory and antifibrotic properties. Here, we investigate the potential therapeutic effects of EW‐7197 in a murine model of ulcerative colitis. EW‐7197 attenuated the colitis disease activity index by improving rectal bleeding, body weight, and degree of stool consistency. EW‐7197 also reduced colorectal tissue damage and the colon histopathological score by reducing crypt loss, mucosal damage, and tissue inflammation. Moreover, EW‐7197 appeared to ameliorate the inflammatory and fibrotic responses by reducing oxidative stress, reducing submucosal edema and inflammatory cell infiltration, downregulating proinflammatory and pro‐fibrotic genes, and inhibiting excessive collagen deposition in inflamed and fibrotic ulcerative colitis tissues. These results suggest that EW‐7197 has potentially useful therapeutic properties against colitis, with clinically translational potential of inhibiting key pathological responses of inflammation and fibrosis in patients with colitis.