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Induced pluripotent stem cell‐derived extracellular vesicles: A novel approach for cell‐free regenerative medicine
Author(s) -
Taheri Behnaz,
Soleimani Masoud,
Fekri Aval Sedigheh,
Esmaeili Elaheh,
Bazi Zahra,
Zarghami Nosratollah
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27775
Subject(s) - regenerative medicine , induced pluripotent stem cell , paracrine signalling , microvesicles , extracellular vesicles , microbiology and biotechnology , stem cell , biology , cell type , cell , somatic cell , extracellular vesicle , embryonic stem cell , microrna , biochemistry , receptor , gene
In recent years, induced pluripotent stem cells (iPSCs) have been considered as a promising approach in the field of regenerative medicine. iPSCs can be generated from patients’ somatic cells and possess the potential to differentiate, under proper conditions, into any cell type. However, the clinical application of iPS cells is restricted because of their tumorigenic potential. Recent studies have indicated that stem cells exert their therapeutic benefit via a paracrine mechanism, and extracellular vesicles have been demonstrated that play a critical role in this paracrine mechanism. Due to lower immunogenicity, easier management, and presenting no risk of tumor formation, in recent years, researchers turned attention to exosomes as potential alternatives to whole‐cell therapy. Application of exosomes derived from iPSCs and their derived precursor provides a promising approach for personalized regenerative medicine. This study reviews the physiological functions of extracellular vesicles and discusses their potential therapeutic benefit in regenerative medicine.