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A review of the molecular pathways mediating the improvement in diabetes mellitus following caloric restriction
Author(s) -
Yaribeygi Habib,
Atkin Stephen L.,
Ramezani Majid,
Sahebkar Amirhossein
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27760
Subject(s) - caloric theory , diabetes mellitus , medicine , endocrinology
Lifestyle modification is the cornerstone of diabetes prevention and treatment. Weight loss through caloric restriction (CR) is effective in improving glycemic control, though it is difficult for patients to follow in practice, and remains critical to achieve optimal glucose homeostasis. In this review, we look at what is known about the molecular pathways involved in CR‐induced insulin sensitivity and improved insulin resistance.