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Mitochondrial dysfunction in diabetes and the regulatory roles of antidiabetic agents on the mitochondrial function
Author(s) -
Yaribeygi Habib,
Atkin Stephen L.,
Sahebkar Amirhossein
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27754
Subject(s) - insulin resistance , oxidative stress , diabetes mellitus , adipokine , medicine , type 2 diabetes mellitus , type 2 diabetes , mitochondrion , pathophysiology , bioinformatics , insulin , obesity , biology , endocrinology , microbiology and biotechnology
Abstract The prevalence of type 2 diabetes mellitus (T2DM) is increasing rapidly with its associated morbidity and mortality. Many pathophysiological pathways such as oxidative stress, inflammatory responses, adipokines, obesity‐induced insulin resistance, improper insulin signaling, and beta cell apoptosis are associated with the development of T2DM. There is increasing evidence of the role of mitochondrial dysfunction in the onset of T2DM, particularly in relation to the development of diabetic complications. Here, the role of mitochondrial dysfunction in T2DM is reviewed together with its modulation by antidiabetic therapeutic agents, an effect that may be independent of their hypoglycemic effect.