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A correlational study between serum asymmetric dimethylarginine level and impaired glucose tolerance patients associated with obesity
Author(s) -
Huang Shan,
Xu Yong,
Peng WenFang,
Cheng Jie,
Li HuiHua,
Shen LiSha,
Xia LiLi
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27743
Subject(s) - medicine , asymmetric dimethylarginine , impaired glucose tolerance , adiponectin , insulin resistance , endocrinology , obesity , type 2 diabetes mellitus , biomarker , diabetes mellitus , type 2 diabetes , arginine , chemistry , biochemistry , amino acid
Asymmetric dimethylarginine (ADMA) plays a vital role in the regulation of insulin sensitivity and has been shown as a potential marker for various disease, including type 2 diabetes mellitus (DM2). However, the correlation between ADMA and impaired glucose tolerance (IGT) and obesity has not been studied. A total of 195 subjects were involved in our study. The characteristics of the subjects in the study cohort were measured and analyzed. We found that the serum ADMA and C‐reactive protein levels were significantly increased in IGT and diabetic patients, whereas the levels of lipoprotein A and adiponectin were decreased, especially in diabetic patients with obesity. The serum ADMA level was positively correlated to a homeostatic model assessment for insulin resistance, and multivariate regression analysis further indicated that ADMA was an independent factor for DM patients with obesity. Our study expands the understanding of the complicated relationship between obesity, insulin resistance, IGT, and ADMA. In addition, we demonstrated that the serum ADMA level could serve as a diagnositic biomarker of the early signs for IGT patients with obesity.