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A review of the anti‐inflammatory properties of antidiabetic agents providing protective effects against vascular complications in diabetes
Author(s) -
Yaribeygi Habib,
Atkin Stephen L.,
Pirro Matteo,
Sahebkar Amirhossein
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27699
Subject(s) - medicine , diabetes mellitus , inflammation , pathophysiology , inflammatory response , type 2 diabetes mellitus , bioinformatics , pharmacology , intensive care medicine , immunology , endocrinology , biology
The global prevalence of Type 2 diabetes mellitus and its associated complications are growing rapidly. Although the role of hyperglycemia is well recognized in the pathophysiology of diabetic complications, its exact underlying mechanisms are not fully understood. In this regard, accumulating evidence suggests that the role of inflammation appears pivotal, with studies showing that most diabetic complications are associated with an inflammatory response. Several classes of antidiabetic agents have been introduced for controlling glycemia, with evidence that these pharmacological agents may have modulatory effects on inflammation beyond their glucose‐lowering activity. Here we review the latest evidence on the anti‐inflammatory effects of commonly used antidiabetic medications and discuss the relevance of these effects on preventing diabetic complications.