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Association between microRNAs expression and signaling pathways of inflammatory markers in diabetic retinopathy
Author(s) -
Shafabakhsh Rana,
Aghadavod Esmat,
Mobini Moein,
HeidariSoureshjani Reza,
Asemi Zatollah
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27685
Subject(s) - diabetic retinopathy , inflammation , microrna , pathogenesis , diabetes mellitus , oxidative stress , signal transduction , retinopathy , vascular permeability , biology , retina , immune system , immunology , bioinformatics , medicine , gene , endocrinology , microbiology and biotechnology , neuroscience , genetics
Diabetic retinopathy is one of the common and serious microvascular complications of diabetes mellitus, as hyperglycemia has metabolic effects on the retina. Hyperglycemia induces increased oxidative stress, which stimulates inflammation pathways and promotes vascular dysfunction of the retina that leads to increased capillary permeability and vascular leakage. One of the main factors involving diabetic retinopathy is the inflammation signaling pathways. In contemporary times, microRNAs (miRNAs) are identified as functional biomarkers for early detection and treatment of numerous diseases specifically diabetic retinopathy. MiRNAs can modulate gene expression through regulation of transcriptional and posttranscriptional of target genes. With that, miRNAs can regulate almost every cellular and developmental process, including the regulation of instinct immune responses and inflammation. The aim of this study is to investigate the role of miRNAs in inflammation pathways and the pathogenesis of diabetic retinopathy.