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The role of nervous system in adaptive response of bone to mechanical loading
Author(s) -
Qiao Yini,
Wang Yang,
Zhou Yimei,
Jiang Fulin,
Huang Tu,
Chen Liujing,
Lan Jingxiang,
Yang Cai,
Guo Yutong,
Yan Shanyu,
Wei Zhangming,
Li Juan
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27683
Subject(s) - adaptive response , nervous system , neuroscience , mechanical system , computer science , control theory (sociology) , biology , engineering , mechanical engineering , control (management) , genetics , artificial intelligence
Bone tissue is remodeled through the catabolic function of the osteoclasts and the anabolic function of the osteoblasts. The process of bone homeostasis and metabolism has been identified to be co‐ordinated with several local and systemic factors, of which mechanical stimulation acts as an important regulator. Very recent studies have shown a mutual effect between bone and other organs, which means bone influences the activity of other organs and is also influenced by other organs and systems of the body, especially the nervous system. With the discovery of neuropeptide (calcitonin gene‐related peptide, vasoactive intestinal peptide, substance P, and neuropeptide Y) and neurotransmitter in bone and the adrenergic receptor observed in osteoclasts and osteoblasts, the function of peripheral nervous system including sympathetic and sensor nerves in bone resorption and its reaction to on osteoclasts and osteoblasts under mechanical stimulus cannot be ignored. Taken together, bone tissue is not only the mechanical transmitter, but as well the receptor of neural system under mechanical loading. This review aims to summarize the relationship among bone, nervous system, and mechanotransduction.