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Expression of myostatin in human hematopoietic cells unveils novel autocrine/paracrine actions for the hormone
Author(s) -
FernándezNocelo Susana,
Gallego Rosalía,
Costoya José A.,
Arce Víctor M.
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27494
Subject(s) - autocrine signalling , paracrine signalling , myostatin , biology , microbiology and biotechnology , haematopoiesis , transforming growth factor , signal transduction , transforming growth factor beta , receptor , endocrinology , stem cell , muscle hypertrophy , biochemistry
Myostatin is a member of the transforming growth factor β (TGFβ) superfamily that has a well‐established role as a mediator of muscle growth and development. However, myostatin is now emerging as a pleiotropic hormone with multiple actions in the regulation of the metabolism as well as several aspects of both cardiac and smooth muscle cells physiology. In addition, myostatin is also expressed in several nonmuscular cells where its physiological role remains to be elucidated in most cases. In this report, we have shown that both myostatin and its receptor system are expressed in blood cells and in hematopoietic cell lines. Furthermore, myostatin treatment promotes differentiation of both HL60 and K562 cells through a mechanism that involves activation of extracellular signal‐regulated kinases 1/2 and p38‐mitogen‐activated protein kinase, thus leading to the possibility that myostatin may be a paracrine/autocrine factor involved in the control of haematopoiesis. In addition, the presence of myostatin expression in immune cells could envisage a novel role for the hormone in the pathogenesis of inflammatory diseases.