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Interleukin‐18 and diabetic nephropathy: A review
Author(s) -
Yaribeygi Habib,
Atkin Stephen L.,
Sahebkar Amirhossein
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27427
Subject(s) - diabetic nephropathy , medicine , diabetes mellitus , biology , endocrinology
The inflammatory response has an important role in the pathophysiology of diabetic nephropathy that is contributed to by inflammatory mediators such as interleukin‐1 (IL‐1), IL‐6, IL‐18, tumor necrosis factor‐α, and macrophage chemotactic protein‐1; however, the role of IL‐18 seems to be more specific than other cytokines in the inflammatory process. IL‐18 is expressed in renal tissue and is upregulated by several stimuli including hyperglycemia. The expression/urinary level of IL‐18 is positively correlated with the progression of diabetic nephropathy and the urinary albumin excretion rate. In this review, we have focused on the molecular pathways modulating the relationship between IL‐18 and diabetic nephropathy.