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Upregulation of long noncoding RNA XIST is associated with poor prognosis in human cancers
Author(s) -
Liu JiLong,
Zhang WenQian,
Zhao Miao,
Huang MingYu
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27400
Subject(s) - xist , long non coding rna , hazard ratio , odds ratio , confidence interval , oncology , biomarker , metastasis , medicine , biology , cancer , meta analysis , downregulation and upregulation , cancer research , x inactivation , genetics , gene , x chromosome
Abstract Growing evidence from recent studies has shown that the X‐inactive specific transcript (XIST), a well‐known long noncoding RNA involved in early embryonic development, is aberrantly regulated in various human cancers. However, the prognostic value of XIST in cancers remains uncharacterized. In this study, we searched PubMed, Web of Science, and Embase to collect all relevant studies, and a meta‐analysis was performed to explore the association of XIST expression with overall survival (OS) and clinicopathological parameters. We demonstrated that high XIST expression was associated with poor OS (hazard ratio = 1.76; 95% confidence intervals [CI], 1.56–1.98; p < 0.001). In addition, increased XIST expression was found to be associated with lymph node metastasis (odds ratio [OR] = 2.06; 95% CI, 1.46–1.90; p < 0.001), distant metastasis (OR = 2.93; 95% CI, 2.00–4.28; p < 0.001), tumor size (OR = 2.66; 95% CI, 1.86–3.81; p < 0.001), poor differentiation (OR = 1.45; 95% CI, 1.00–2.10; p = 0.049), and advanced tumor stage (OR = 3.35; 95% CI, 2.25–5.00; p < 0.001), but not with age (OR = 0.82; 95% CI, 0.59–1.15; p = 0.251) or gender (OR = 0.92; 95% CI, 0.70–1.19; p = 0.512). Our meta‐analysis showed that XIST may be a useful common biomarker for predicting prognosis in patients with cancer.