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Circular RNA in cardiovascular disease
Author(s) -
Altesha MAshraf,
Ni Tiffany,
Khan Afaan,
Liu Kexiang,
Zheng Xiufen
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27384
Subject(s) - circular rna , pathogenesis , coronary artery disease , disease , medicine , myocardial infarction , cardiology , cardiomyopathy , diabetic cardiomyopathy , fibrosis , heart failure , bioinformatics , rna , biology , gene , genetics
Circular RNA (circRNA) are endogenous transcripts that display differential expression across species, developmental stages, and pathologies. Their lack of free ends confers increased stability when compared with linear transcripts, making them ideal candidates for future diagnostic biomarkers and therapeutic interventions. Increasing evidence has implicated circRNA in the pathogenesis of multiple cardiovascular diseases. In this paper, we summarize current understanding of circRNA biogenesis, properties, expression profiles, detection methods, functions, and their implication in cardiac pathologies including/ischemia reperfusion injury, myocardial infarction, cardiac senescence, cardiac fibrosis, cardiomyopathy, cardiac hypertrophy and heart failure, atherosclerosis, coronary artery disease, and aneurysm.