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The mechanisms of DIRAS family members in role of tumor suppressor
Author(s) -
Li Xueli,
Liu Shuiping,
Fang Xiao,
He Chao,
Hu Xiaotong
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27376
Subject(s) - suppressor , biology , microbiology and biotechnology , genetics , cancer research , gene
DIRAS family is a group of GTPases belonging to the RAS superfamily and shares homology with the pro‐oncogenic Ras GTPases. Currently, accumulating evidence show that DIRAS family members could be identified as putative tumor suppressors in various cancers. The either lost or reduced expression of DIRAS proteins play an important role in cancer development, including cell growth, migration, apoptosis, autophagic cell death, and tumor dormancy. This review focuses on the latest research regarding the roles and mechanisms of the DIRAS family members in regulating Ras function, cancer development, assessing potential challenges, and providing insights into the possibility of targeting them for therapeutic use.