z-logo
Premium
The genetic factors contributing to hypospadias and their clinical utility in its diagnosis
Author(s) -
Joodi Marjan,
Amerizadeh Forouzan,
Hassanian Seyed Mahdi,
Erfani Marjan,
GhayourMobarhan Majid,
Ferns Gordon A.,
Khazaei Majid,
Avan Amir
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27350
Subject(s) - hypospadias , homeobox , biology , sonic hedgehog , testis determining factor , fibroblast growth factor receptor 1 , androgen insensitivity syndrome , androgen receptor , disorders of sex development , genetics , prostate cancer , endocrinology , gene , fibroblast growth factor , cancer , receptor , y chromosome , gene expression
Hypospadias is among the most common congenital malformations in male neonates. It results from abnormal penile and urethral development, but is a multifactorial disorder that is highly heterogeneous, with several genetic and environmental determinants. Monogenic and chromosomal abnormalities are present in approximately 30% of cases, although the genetic factors contributing to hypospadias remain unknown in 70% of cases. While defects in androgen synthesis can lead to this malformation, mutational analyses have shown several genes, such as sonic hedgehog, fibroblast growth factors, bone morphogenetic proteins, homeobox genes, and the Wnt family, are involved in the normal development of male external genitalia. Mutations in the genes of penile development (e.g., HOX, FGF, Shh) and testicular determination (e.g., WT1, SRY), luteinizing hormone receptor, and androgen receptor have also been proposed to be implicated in hypospadias. Here we review the recent advances in this field and discuss the potential genes that could determine the risk of hypospadias.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here