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PI3k/AKT signaling pathway: Erythropoiesis and beyond
Author(s) -
Jafari Mahjoobeh,
Ghadami Elham,
Dadkhah Tahereh,
AkhavanNiaki Haleh
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27262
Subject(s) - erythropoiesis , pi3k/akt/mtor pathway , autophagy , biology , protein kinase b , haematopoiesis , microbiology and biotechnology , microrna , transcription factor , signal transduction , stem cell , apoptosis , gene , genetics , medicine , anemia
Erythropoiesis is a multi‐step process that involves the differentiation of hematopoietic stem cells into mature red blood cells (RBCs). This process is regulated by several signaling pathways, transcription factors and microRNAs (miRNAs). Many studies have shown that dysregulation of this process can lead to hematologic disorders. PI3K/AKT is one of the most important pathways that control many cellular processes including, cell division, autophagy, survival, and differentiation. In this review, we focus on the role of PI3K/AKT pathway in erythropoiesis and discuss the function of some of the most important genes, transcription factors, and miRNAs that regulate different stages of erythropoiesis which play roles in differentiation and maturation of RBCs, prevention of apoptosis, and autophagy induction. Understanding the role of the PI3K pathway in erythropoiesis may provide new insights into diagnosing erythrocyte disorders.