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Fusobacterium nucleatum and colorectal cancer: A mechanistic overview
Author(s) -
Hashemi Goradel Nasser,
Heidarzadeh Siamak,
Jahangiri Samira,
Farhood Bagher,
Mortezaee Keywan,
Khanlarkhani Neda,
Negahdari Babak
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27250
Subject(s) - fusobacterium nucleatum , colorectal cancer , carcinogenesis , cancer research , cancer , biology , immune system , medicine , immunology , microbiology and biotechnology , bacteria , genetics , porphyromonas gingivalis
Colorectal cancer (CRC) is the third most prevalent cancer in the world. There are many risk factors involved in CRC. According to recent findings, the tumor microenvironment and feces samples of patients with CRC are enriched by Fusobacterium nucleatum . Thus, F. nucleatum is proposed as one of the risk factors in the initiation and progression of CRC. The most important mechanisms of Fusobacterium nucleatum involved in CRC carcinogenesis are immune modulation (such as increasing myeloid‐derived suppressor cells and inhibitory receptors of natural killer cells), virulence factors (such as FadA and Fap2), microRNAs (such as miR‐21), and bacteria metabolism. The aim of this review was to evaluate the mechanisms underlying the action of F. nucleatum in CRC.