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Therapeutic potency of pharmacological adenosine receptors agonist/antagonist on cancer cell apoptosis in tumor microenvironment, current status, and perspectives
Author(s) -
Soleimani Anvar,
Bahreyni Amirhossein,
Roshan Mostafa K.,
Soltani Arash,
Ryzhikov Mikhail,
Shafiee Mojtaba,
Soukhtanloo Mohammad,
Jaafari Mahmoud R.,
Mashkani Baratali,
Hassanian Seyed M.
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27249
Subject(s) - agonist , potency , antagonist , pharmacology , adenosine , adenosine receptor , receptor , apoptosis , tumor microenvironment , cancer , medicine , cancer research , chemistry , in vitro , biochemistry
The hypoxic niche of tumor leads to a tremendous increase in the extracellular adenosine concentration through alteration of adenosine metabolism in the tumor microenvironment (TME). This consequently affects cancer progression, local immune responses, and apoptosis of tumor cells. Regulatory effect of adenosine on apoptosis in TME depends on the cancer cell type, pharmacological characteristics of adenosine receptor subtypes, and the adenosine concentration in the tumor niche. Exploiting specific pharmacological adenosine receptor agonist and antagonist inducing apoptosis in cancer cells can be considered as a proper procedure to control cancer progression. This review summarizes the regulatory role of adenosine in cancer cell apoptosis for a better understanding, and hence better management of the disease.