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The role of microRNAs in 5‐FU resistance of colorectal cancer: Possible mechanisms
Author(s) -
Marjaneh Reyhaneh Moradi,
Khazaei Majid,
Ferns Gordon A.,
Avan Amir,
AghaeeBakhtiari Seyed Hamid
Publication year - 2019
Publication title -
journal of cellular physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.529
H-Index - 174
eISSN - 1097-4652
pISSN - 0021-9541
DOI - 10.1002/jcp.27221
Subject(s) - microrna , colorectal cancer , suppressor , mechanism (biology) , oncogene , cancer , cancer research , medicine , bioinformatics , biology , gene , cell cycle , genetics , philosophy , epistemology
Abstract Colorectal cancer (CRC) is one of the most common cancers globally. Despite recent advances in therapeutic approaches, this cancer continues to have a poor prognosis, particularly when diagnosed late. 5‐Fluorouracil (5‐FU) has been commonly prescribed for patients with CRC, but resistance to 5‐FU is one of the main reasons for failure in the treatment of this condition. Recently, microRNAs (miRNAs) have been established as a means of modifying the signaling pathways involved in initiation and progression of CRC and their role as oncogene or tumor suppressor have been investigated in various studies. Moreover, miRNAs through various mechanisms play an important role in inducing tumor resistance or sensitivity to anticancer drugs. Detecting and targeting these mechanisms may be a new therapeutic approach. This review summarizes the current knowledge about the potential roles of miRNAs in 5‐FU resistance, with particular emphasis on molecular mechanism involved.